Abstract
Summary and Conclusion
White mice, exposed to X-radiation, given a medium dose of 350 r in a single exposure was found satisfactory under the experimental conditions described in the text. Folic acid and pyridoxine hydrochloride were used as possible protective agents. No appreciable effect of these drugs on the hemopoietic system was noted. On the other hand, it was found that 15 γ of folic acid injected daily during a period of 7 days prior to radiation and 15 days after radiation prolonged significantly the survival time of the irradiated mice. Similar observations were made with pyridoxine hydrochloride. Thus, irradiated mice injected with 50 γ of pyridoxine hydrochloride intramuscularly daily 7 days prior to radiation and 13 days post-radiation, extended significantly the life span of the irradiated mice, as compared with the irradiated, unmedicated mice.
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