Abstract
Summary
1. Dibenamine hydrochloride, a new sympatholytic and adrenolytic drug was administered intravenously in the dosage of 5 mg/kg of body weight to normotensive and hypertensive subjects. 2. Reduction to normal or below normal levels in resting arterial blood pressure was observed only in benign or moderately advanced essential hypertension, but not in the malignant phase. Orthostatic hypotension occurred in both normotensive and hypertensive subjects. 3. The depressor effect started at the end of the infusion and lasted 24 to 72 hours. 4. All side reactions were transient, and major side reactions occurred only in a few instances. 5. The role of the neurogenic factor in essential hypertension is discussed. The usefulness of dibenamine in evaluating the neurogenic element is suggested.
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