Abstract
Summary
The perfusion fluid from isolated hearts of cats, rabbits and rats contains creatinine and histamine. There is a species variation in the excretion of these substances. When digitoxin (1:40,000) is added to the perfusion fluid, the creatinine output of the heart is not significantly altered in the 3 species studied. However, the histamine output of the cat and the rabbit heart decreases, while that of the rat heart remains unchanged. The isolated rat heart is much more resistant toward digitoxin than the cat and rabbit hearts.
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