Abstract
Summary
On incubating insulin under sterile conditions in acid saline with 2 moles of oxophenarsine (3-an1ino-4-hydroxyphenylarsenoxide hydrochloride) for each atom of sulfur contained in the insulin, it was found (by blood sugar determinations) that the effect of the treatment was to prolong the action on the blood sugar beyond that of untreated insulin. However, after 2 weeks standing this delayed action effect had disappeared and the material gave a blood sugar curve identical to that of the control insulin. Possible mechanisms of the interaction of oxophenarsine and insulin are briefly discussed.
Get full access to this article
View all access options for this article.