Abstract
Summary
(1) Coramine produces a great increase in the liver wt/body wt ratio in growing rats. (2) This increase which is manifest within 5 days or less and which is still apparent for at least 28 days cannot be prevented by the ingestion of choline or methionine. (3) The percentage of water and glycogen in these livers is essentially the same as in the controls. Coramine causes some elevation in the fat content which may be prevented by the administration of choline or methionine. (4) On microscopic examination, aside from the fat globules observed in the livers of rats receiving coramine alone, no marked pathological changes were evident. Binucleate cells and mitoses were present in large numbers.
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