Abstract
Conclusion
Crystalline procaine penicillins G and dihydro-F are highly effective antibacterial agents in vitro and in vivo.
Crystalline procaine penicillins G and dihydro-F, in oil, when injected intramuscularly in rabbits in a single dose of 30,000 units (0.1 cc) per kg body weight, in most instances produces blood levels lasting 24 to 30 hours or longer.
Preliminary observations in man indicate that a single intramuscular injection of 300,000 units of crystalline procaine penicillin G in oil may produce detectable blood levels lasting 'from 24 to 48 hours while penicillin may be excreted in the urine for at least 48 to 60 hours.
Preliminary observations suggest that the toxicity of crystalline procaine penicillin is probably low.
Other water-insoluble salts of penicillin when suspended in oil also produce marked prolongation of blood levels.
Get full access to this article
View all access options for this article.