Abstract
Summary
Male rats having mild alloxan diabetes were used as test animals in this study. They were force-fed a medium carbohydrate diet. Two synthetic estrogens were tested, each of which represents a chemically different series of compounds than have previously been tested for diahetogenicity. Substance 1 was 2,4-di(p-hydroxyphenyl)-3-ethyl hexane, and Substance 11 was 1,2-dimethyl-2-carboxy-7-snethoxy-1,2,3,4,9,10-hexahydrophenathrene. Substance I caused exacerbation of the diabetes in 5 out of 6 test animals. The sixth rat did not have a spontaneous glycowria and failed to respond to the estrogen. Substance 11 intensified the glycosuria in all 6 test animals and appeared to be the more potetit of the two compounds. When the injections were stopped the glycosuria decreased to its pre-injection level or below.
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