Abstract
Conclusions
1. Podophyllin exerts a selective damaging effect on mouse tumor cells in tissue culture over the concentration range 0.08-20.0 mg/1. 2. This damaging effect is more easilv reversible in normal than in tumor cells. 3. Podophyllotoxin is not as effective as podophyllin in causing selective tumor damage. 4. In vivo studies with tumor-bearing mice confirm the selective tumor damaging effects of podophyllin which were first noted in tissue culture preparations.
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