Abstract
Summary
1. Following prolonged daily administration of crude bacitracin concentrates in dogs and monkeys, no significant changes in blood morphology were observed. 2. Injection of bacitracin solution (6000 units per cc) into the shaved abdominal skin, and instillation of bacitracin (1200 units per cc) into the conjunctival sac of the rabbit caused little irritation. 3. Repeated intramuscular injection of 1000 units of bacitracin per kg 3 times each day for 23 days into the dog produced local induration. 1500 units per kg twice a day for 45 days in the same area in monkeys produced both induration and small areas of necrosis. 4. In the dog, urine samples remained negative for sugar and albumin while in the monkey, sugar and albumin appeared in the urine as the animals continued on test. 5. Large doses of bacitracin, approximating the LD50? produced damage to the renal tubules, with tubular necrosis in the mouse. In the rat and the dog, the lesions were, insignificant, while in the monkey, necrotic cells were found in two instances only, and then in comparatively insignificant numbers as contrasted with the mouse.
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