Abstract
Summary
Suspensions of mouse brain tissue infected with the M-H (Mouse-Hamster) virus when incubated with a pure culture of the Micrococcus varians organism were found to have a markedly reduced oral infectivity for the white Swiss mouse. In spite of this reduction in oral infectivity there is no change in the infectivity of the virus material containing the micrococcus when it is injected subcutaneously. Filtrates of the micrococcus culture do not appear to inhibit the oral infectivity of the virus. It is suggested that the M-H virus may have been absorbed on the Micrococcus varians organism, and is thus not as readily available for invasion through the intestinal tract or that the virus itself may have been modified so that its oral infectivity has been reduced while its infectivity by subcutaneous inoculation is unchanged.
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