Abstract
Summary
As judged by the intraperitoneal toxicity in mice, Neohetramine is about one-half as toxic as other antihistaminic agents. Weanling rats, receiving as much as 200 mg of Neohetramine per kg body weight per day over a period of 3 months, grew at a normal rate, exhibited no abnormalities in blood morphology and developed no organ pathology. Neohetramine showed marked activity against the bronchiolar and capillary actions of histamine. Quantitative estimates of the amount of histamine antagonized by Neohetramine varied with the method of testing. Neohetramine conferred protection against anaphylactic shock in guinea pigs actively sensitized to horse serum. The implications of these findings are discussed.
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