Abstract
Summary
The effects of dithiobiuret on electrical activity of cortex were tested upon 4 cats, 2 dogs, and one rat. Normal animals or the same animals were used as controls. Twenty-two rats were used in chronic administration and 12 of these were used to determine cortical threshold to electrically induced convulsions. The significant findings were: (1) a lack of detectable electroence-phalographic change in cortical activity of animals tested after immediate or prolonged administration of dithiobiuret, (2) cortical threshold to electrically induced convulsions of rats was raised by an average of approximately 26 volts and (3) the form of convulsion in intoxicated rats was altered.
Conclusion. Dithiobiuret is an effective anti-convulsant in rats only when they are intoxicated. The site of action of ditbiobiuret is within the central nervous system; the most probable site is the efferent system of the spinal cord.
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