Canine Epilepsy Caused by Flour Bleached with Nitrogen Trichloride (Agene). II. Role of Amino Acids. ∗

Abstract

Summary

When an amino acid mixture approximating the composition of gliadin is treated with nitrogen trichloride gas (NCI₃) this mixture is so altered as to make it con-vulsant for dogs when given intravenously. The convulsant activity is most readily demonstrated in dogs which have been on a bleached (agenized) flour diet for 5 to 7 days, presumably because these animals have accumulated sufficient quantity of the toxic material via the alimentary tract, to make them highly susceptible to an additional increment received via the blood stream.