Abstract
Summary
The sporozoites of P. cathe-merium 3H2, an organism causing severe infections in canaries, were injected intramuscularly in large numbers into full-grown barnyard hens, In the respective trials the in-jectum consisted of (a) the gauze filtrate of infected mosquitoes ground in fresh hen plasma; (b) the gauze filtrate of infected mosquitoes ground in hen plasma obtained after allowing the drawn blood to stand for one hour at room temperature; (c) the gauze filtrate of infected mosquitoes ground in Locke's solution; (d) whole canary blood to which was added the gauze filtrate of infected mosquitoes ground in Locke's solution, the mixture being incubated at the temperature of hen blood for 2 1/2 hours before using for injection. None of the injected hens in any of the trials became infected and all of the canaries injected as controls did become infected.
Two human volunteers were bitten, respectively, by 11 and 17 mosquitoes infected with P. cathemerium 3H2; neither of the individuals became infected so far as could be determined by a study of peripheral blood smears and subinoculation of blood inta canaries.
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