Abstract
Summary
The ureters were ligated in 6 dogs, and phthalylsulfathiazole was administered orally in doses of 0.5 to 0.75 g/kg/day for 3-6 days pre-operatively and postoperatively until death. Two of these animals showed at autopsy an increased vascularity of the fascial sheath covering the perirenal fat, 5 animals showed perirenal sheath hemorrhage, and 3 animals had fresh free blood in the abdominal cavity.
The ureters were ligated in 6 control dogs, and they received no phthalylsulfathiazole. Four of these animals showed at autopsy an increased vascularity of the perirenal sheath. None of the animals showed perirenal hemorrhage.
It was found that both ureter ligation and phthalylsulfathiazole administration are necessary for production of the perirenal lesions. It appears that the perirenal hemorrhage is due to vascular changes since no abnormalities in prothrombin time, bleeding, clotting, and clot retraction time, red blood cell counts or platelet counts were demonstrated. The average total blood sulfathiazole concentration at the time of death in the test animals was 2.9 mg %.
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