Abstract
Summary
The relationship of the serum protease to the action of peptone was investigated using soybean trypsin inhibitor and protamine. Soybean trypsin inhibitor inhibited fibrinolysis by chloroform serum (activated serum protease). It inhibited the fibrinolysis occurring in peptone shock in the anterior dog and also the release of histamine from rabbit blood cells in vitro on the addition of peptone. Protamine accelerated fibrinolysis in the anterior animal and also lysis by the serum protease in the presence of the natural serum protease inhibitor.
We wish to acknowledge the hospitality of Dr. C. H. Best in the Department of Physiology, University of Toronto. We are indebted to Dr. E. Fidlar for the platelet counts.
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