Abstract
Summary
1. Twenty-two of 25 dogs fed a kennel diet of selected table scraps to which was added each day for 8 weeks or longer 3.0 cc/kg of cod liver oil developed typical arterial lesions when they died in uremia 7 to 35 days after the experimental production of renal insufficiency.
2. When vitamin E (mixed natural tocopherols, 2.5 to 4.0 mg/kg/day by mouth) was administered along with the diet, none of 4 dogs subjected to the same experimental procedures developed any arterial lesions.
3. Vitamin E was equally effective in preventing or retarding the arterial lesions when its administration by mouth was started 0, 1, and 2 days after renal insufficiency was induced.
Get full access to this article
View all access options for this article.