Abstract
Summary
1. An attempt has been made to determine the depth of penetration, and the amount of deposition in the respiratory system of nebulized dilute Tndia ink, aqueous gentian violet solution and aqueous ferric ammonium sulfate solution in 2 mice, 11 rats, 2 rabbits and 1l dogs.
The substances were found to be deposited in decreasing amounts in the oropharynx, larynx, bifurcation of the trachea, the bronchi and bronchioles of the animals. The amounts of deposited substances in the bronchi and bronchides were so small as to make microscopic detection difficult. In no case was any nebulized substance found to have reached the alveoli.
3. There is no evidence to support the theory that pulmonary lesions can be treated by topical application with commercial nebulizers.
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