Abstract
Summary
1. When serum with abnormally hiqh gamma globulin concentration 1s diluted with a solution containing a certain small amount of copper or zinc sulfate, a turbid precipitate forms and the optical density of the suspension is proportional to the concentration of gamma globulin.
2. Such an estimation of increase in gamma globulin really measures the total globulin elevation in pathological sera because hyperglobulinemia is almost always due to an alteration in the gamma globulin fraction of the serum.
3. The test has proved useful for determining alterations in gamma globulin during the course of an acute illness such as infectious hepatitis.
4. It was found to be of particular value in detecting persistent liver disease following infectious hepatitis. In a group of 41 patients with cirrhosis of the liver the reaction was positive in every case.
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