Abstract
Summary
1. Oral administration of an aqueous solution containing 0.05 g of saccharin caused a decrease of 12 to 16% in the blood sugar level of normal individuals. Water alone had no significant influence.
2. The decrease of blood sugar was not proportional to the saccharin dosage.
3. Administration of the saccharin in 4 portions during a 40 minute period increased the duration of hypoglycemia.
4. It is suggested that this phenomenon is due to the influence of the sweet taste, which may act by means of a reflex mechanism to induce insulin secretion.
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