Abstract
Summary
Experiments on dogs showed that dibenamine:
1. Induces a slight fall of arterial pressure;this hypotension depends mainly on a peripheral vasodilator action.
2. Has no direct effect upon the heart rate.
3. Produces no lasting decrease of the carotid sinus vasopressor reflexes; it never induces a reversal of these reflexes, while the same dose reverses completely the action of epinephrine on blood pressure and blood vessels
4. Does not affect the tachycardic action of epinephrine.
5. Has no marked effect upon the hypertensive properties of nicotine, ephedrine and pituitrin.
6. Produces a reversal of the asphyxia hypertension.
7. Induces, in atropinized dogs, a reversal of the vasopressor action of acetylcholine.
8. May decrease, but does not produce a reversal of the vasomotor responses of sympathetic origin.
9. Is primarily a powerful adrenolytic, but a weak sympathicolytic agent.
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