Renal Hemodynamic Effects of Adrenaline and “Isuprel”

Abstract

Comment and Summary

The increased pressor responsiveness to adrenaline caused by injection of Et₄N is shown to be associated with an increase in renal vasoconstriction. The depressor response to injection of “Isuprel,” the N-isopropyl homologue of adrenaline, is shown to be associated with renal vasodilation. The depressor, cardioaccelerator and renal vasodilator effects of injection of “Isuprel” are augmented by prior injection of tetraethylammonium. On the assumption that the effects of tetraethylammonium are due to blockinq of autonomic ganglia, 4 we conclude that inhibition of these ganglia increases vascular responsiveness to typical vasoconstrictor and vasodilator sympatheticomimetics.