Abstract
Summary
Acriflavine; 3-nitro-6, 7-dimethoxy 9 - (2-phenyl-4-diethylaminobutylamino) acridine; and 3-nitro-6, 7-dimethoxy 9 - (2-hydroxy-3-diethylaminopropylamino) acridine inhibited yolk sac infections of chick embryos with the agents of feline pneumonitis, lymphogranuloma venereum, and meningopneumonitis. The first two compounds were less active against the virus of mouse pneumonitis, but the last-named inhibited this agent in chick embryos.
Proflavine, atabrine, and drugs closely related to the above-mentioned nitroacridines, except for substitution of C1 for NO2, had no significant inhibitory action. 3-nitro-9-aminoacridine was intermediate in its effect.
Respiratory infections in mice caused by the agent of feline pneumonitis were retarded by the two nitroacridines, but these drugs showed slight or no effect in mice against intranasal infection with the agents of mouse pneumonitis, lymphogranuloma venereum, and meningopneumonitis.
Get full access to this article
View all access options for this article.