Abstract
Summary
Each of 13 strains of gramnegative bacilli that were highly resistant to streptomycin was passed through 100 serial subcultures in broth. Evidence was obtained which indicated that appreciable numbers of streptomycin sensitive cells appeared in 2 of these strains: in one instance after 28 subcultures and in the other after 59 transfers. The 11 remaining strains appeared to retain their resistance.
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