Abstract
Conclusions
The quantitative values of prothrombin as determined by the method of Quick using rabbit brain thromboplastin can be correlated with dicoumarol therapy and clinicd hcmorrhayic tendencies. The levels of prothrumbin as determined by the Ruscell viper venom modification of Quick's method cannot at all times be correlated with the clinical state of the patient and the dicoumarol therapy. The control of dicoumarol therapy by the Russell viper venom method for prothrombin determination is a dangerous procedure. The results may be interpreted as being in a safe therapeutic level of prothrombin when actually the patient may be in a critical potential or actual hemorrhagic condition, this state being determined both by the Quick method and clinical observations.
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