Abstract
Summary
The relative effect of parenteral versus oral administration of cobaltous chloride on erythrocyte and hemoglobin formation in rats has been determined. Daily subcutaneous iujection of 2.5 mg/kg of body weight, over a period of 6 weeks, resulted in an increase of more than 30% in the number of erythrocytes per cu mm and in grams of hemoglobin per 100 ml of blood. To produce a similar effect from oral administration of cobaltous chloride, within the same period of time. 40 mg/kg of body weight was required. These dosaqes are without significant toxic effects. Rats which received 10 mg cobaltous chloride/kg daily, subcutaneously, averaged 24% weight loss by the end of 6 weeks. Rats which received 40 mg/kg body weight, subcutaneously, did not survive beyond 8 days.
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