Abstract
Summary
Mice on a purified diet with added succinylsulfathiazole developed no signs of pteroylglutamic acid deficiency within 6 weeks. When a crude synthetic preparation of a pteroylglutamic acid antagonist was added to the diet a syndrome appeared which was characterized by slow growth, anemia and leucopenia. Pteroylglutamic acid prevented the appearance of the syndrome. The development of pteroylglutamic acid deficiency in chicks on a purified diet was aggravated by adding the antagonist to the diet, and the effects of the antagonist were reversed by pteroylglutamic acid.
Get full access to this article
View all access options for this article.