Abstract
Summary
Diethylstilbestrol caused a prolongation of the bleeding and coagulation time in dogs, thrombopenia, an increase in the capillary fragility, leukocytosis and a gradual anemia. In 2 dogs death resulted.
The changes in the circulating blood and bone marrow produced by diethylstilbestrol appear to be temporary in some instances. The return to normal, despite the continued administration of the drug, might indicate that a tolerance to diethylstilbestrol had been acquired. This return to normal was as prompt and as great without as with the administration of alpha-tocopherol.
The present studies failed to confirm the report of Skelton, Shute, et al. that alpha-tocopherol exerts an antipurpuric action on the hemorrhagic diathesis induced in dogs by diethylstilbestrol.
Get full access to this article
View all access options for this article.