Abstract
Summary
1. The condensation with BAL enhances significantly the trichomonacidal effect of Mapharsen.
2. The resulting compound, i.e., 2-amino-4-[methylolcyclo- (ethyl(ened, imercaptoarsino)) -phenol, in the form of its hydrochloride, compares favorably with acetarsone, aldarsone, and bromoacetic acid as to trichomonacidal effect.
3. The increase of trichomonacidal activity brought about by condensation with BAL is considered as associated with the concurrent increase in lipophilic character.
4. A comparison between the arsonic and the stibonic acid derived from the identical organic radical shows the arsenic compound to be inactive and the analogous antimony compound to be active and superior to acetarsone and aldarsone as to tricho monacidal effect.
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