Abstract
Summary
1. Twenty mg % of 3-n-amyl-cyclopentane-carboxylic acid mono-ester of sodium N-glycerophosphate (“V”) was found to give complete inhibition in vitro, while it required only 10 mg % of 3-n-amyl-cy-clopentane-carboxylic acid di-ester of sodium /3-glycerophosphate (“W”) to give similar results.
2. The toxicity of 3-n-amyl-cyclopentane-carboxylic acid mono- and di-esters of sodium N-glycerophospliate for the chick embryo appears to be similar to that of the parent substance, sodium 3-n-amyl-cyclopentane-carboxylate. The lethal dose for chick embryos for compounds “V” and “W” is 5.0 mg. The less soluble parent compound “C” in concentrations of 4.0 mg permitted only 3% survival.
In white mice all 3 compounds had a narcotic effect and produced hemorrhages at the site of injection but the hemorrhage was less marked when compound “V” was used. Compound “C” in doses of 10 mg per 20 g mouse had a more rapid killing effect than either UV“ or ”W.” Five mg of UCV gave S0% mortality, while “V” and “W” in the same dose gave only 10%.
3. When the tuberculostatic effect of “V” and aW“ was tested on the chorio-allantoic membrane of the chick embryo the chemotherapeutic effectiveness of ”W,“ the di-ester, was twice as great as the mono-ester ”V.”
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