Abstract
Summary
It may be stated that chronic administration of amidone in the monkey does not lead to a condition of physical dependence on this drug such as is noted with morphine. Tolerance to this drug does not develop, but on the contrary an increased susceptibility to its depressant effect occurs. Crossed tolerance from amidone to morphine does not occur but chronically morphinized monkeys do exhibit some crossed 1 tolerance to amidone. The later is only minimal and not comparable in degree to that which occurs from one morphine derivative to another. Amidone produces an acute depression which is maximum in 90 minutes and is of 4 to S hours' duration in this animal. The lethal dose in the monkey lies between 10 and 20 mg/kg and death occurs from respiratory failure.
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