Abstract
Discussion and Summary
The experiments reported here revealed that the anti-histaminic compounds pyribenzamine, bena-dryl and hetramine in the 3-day-old chick embryo cause bradycardia, stoppage of the heart beat and occasionally hemorrhages. It appears likely that the chick embryo can be used to advantage in studies on the relative toxicity of various antihistaminic compounds. The drugs do not prevent the inverted ana-phylactic shock, which is due to factors other than histamine.
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