Abstract
Summary
A study was made of the local anesthetic effect of β-dimethylaminoethyl benzhydryl ether hydrochloride (benadryl) when injected into the skin of human beings. The results were as follows: 1. By means of electric algesimetric determinations, benadryl in dilutions of 1:500, 1:1,000, 1:5,000, 1:10,000 and 1:20,000 was found to possess anesthetic potencies similar to those of procaine in dilutions of 1:200, 1:400, 1:800, 1:1,600 and 1:3,200 respectively. 2. Benadryl in concentrations greater than 1:500 (2 mg per cubic centimeter) proved to be exceedingly irritating when injected into human skin, causing tissue necrosis and ulceration in 4 of 10 subjects tested.
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