Abstract
Summary
1. Dibenzyl - β - chloroethyl amine hydrochloride (dibenamine) inhibits the vasoconstrictor action of epinephrine, as tested in the Laewen-Trendelenburg preparation in the frog. Its adrenolytic action is very potent, for it blocks even large amounts of epinephrine (50-1000 γ). 2. When the action of large amounts of epinephrine is completely inhibited by dibenamine, both hypertensin and nicotine still exhibit a marked vasoconstrictor activity. 3. The peripheral locus of action of dibenamine seems to be at the neuroeffector cells or between the postganglionic nerve endings and the latter.
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