Abstract
Conclusions
Six daily doses of 49 billion living Shigella sonnei administered by gavage to white mice stimulated complete immunity to intraperitoneal injection of 16 to 160,000 MLD of homologous culture suspended in sterile mucin. Killed bacteria in doses of 1.1 billion and living bacteria in doses of 1.4 billion stimulated immunity, the titer of which increased with the number of daily doses. There was no significant difference in the immunizing effects of living and killed culture. Mice which drank killed broth culture in place of water for 21 days were immune against 2 to 2048 MLD of homologous culture injected intraperitoneally.
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