Abstract
Summary and Conclusion
The erythrocytes of 2 patients with acquired hemolytic anemia and spherocytosis have been shown to be readily agglutinated by an immune rabbit serum containing an anti-human globulin antibody. Since both patients have exhibited abnormal hemolytic activity for transfused cells this finding is compatible with the existence of an immune body type of hemolytic agent as the cause of the accelerated hemolysis.
Evidence has been presented to show that the immune substance can be separated from patients' cells by heating the cells to 56° C for 5 minutes and can then be combined with normal cells. The similarity of this immune body to the Rh blocking antibody is discussed. The demonstration of the presence or absence of an immune body attached to the erythrocytes should become a routine procedure in the study of hemolytic anemias.
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