Abstract
Summary
When ANTU was fed chronically to rats for 2 years in concentrations of 50 to 800 ppm in the diet, the concentrations from 100 to 800 ppm were toxic. Externally, the rats were stunted and showed spectacle eyes, thinning and coarsening of the hair and deformities of the legs and feet. Histopathological changes consisted of hyperplasia of the thyroid, hyperplasia of the splenic pulp, hyaline changes in the cytoplasm of the centrolobular hepatic cells, a slight to moderate decrease in the thickness of the adrenal cortex, calcified tubular casts in the renal medulla, slight myeloid hyperplasia of the bone marrow, and slight modifications in bone structure. The degree of injury in each case was related to the concentration of the AXTU. The concentrations of 600 and 800 ppm ANTU produced a marked tolerance.
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