Abstract
Summary
The majority of certain compounds tried, and related in chemical structure to acetone, particularly isopropyl alcohol, were found to raise considerably the threshold for electrical convulsions in rats. Isopropyl alcohol increased the cortical depressant efficiency of diphenylhydantoin without demonstrable motor depression or narcosis. Some other alcohols and certain sugars and organic acids were ineffective. The possible significance of the isopropyl group (or isopropanol) for benefits from ketogenic agents in epilepsy and for developing new or improving old antiepileptic agents is discussed.
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