Abstract
Summary
The avidin combinability of a number of compounds having some structural similarity to biotin was investigated. The specificity of the avidin reaction was emphasized by the finding that of the 19 compounds studied avidin possessed significant affinity only for δ- (2,3-ureylene-cyclohexyl-) valeric acid (XVII), γ- (3,4-ureylene-cyclohexyl)-butyric acid (XVIII) and δ-(3,4-ureylene-cyclohexyl )-valeric acid (XIX). The relative affinity ratio for Compound XVII was found to be about 14. Compounds XVIII and XIX, although definitely capable of combining with avidin, had affinity ratios too high for practical measurement.
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