Abstract
Summary
A study has been made of the effect of R-E blockade upon natural or induced immunity of rabbits to the Shwartzman phenomenon. Striking results were obtained when Thorotrast was used as the blocking agent. Rabbits that had shown a natural immunity, or had become immune following a series of previous Shwartzman reactions, responded, after the injection of Thorotrast, by developing typical areas of hemorrhagic necrosis. In addition to eliciting a positive skin reaction in a previously immune animal, R-E blockade increased the injurious effect of the bacterial toxin, causing death in the majority of animals tested.
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