Role of Hemoconcentration in Production of Gastric and Duodenal Ulcer Following Experimental Burns. ∗

Abstract

Conclusions

Evidence is presented to show that increased concentration of the blood following burns is an important factor in the occurrence of gastro-duodenal ulcer after experimental burns. (The occurrence of gastro-intestinal congestion, erosion and/or ulcer in burns is directly related to the occurrence of hemoconcentration).

Moreover, gastro-intestinal abnormality following burns, even when accompanied by histamine administration, may be prevented by avoidance of the hemoconcentration of burns by proper therapy.

The incidence of gastric and/or duodenal ulceration provoked by hemoconcentration in burns is markedly increased when histamine-in-beeswax administration accompanies the burn.