Antagonism of the Hemorrhagic Syndrome Induced by Derivatives of 3-Hydroxy-l,4-Naphthoquinone. ∗

Abstract

Summary

The development of the hypoprothrombinemia and hemorrhagic lesions, which occurred in the albino rat as the result of ingestion of various 2-substituted-3-hy-droxy-l,4-naphthoquinones, could be prevented either partially or completely by simultaneous administration of 2-methy 1-1,4-naphthoquinone or vitamin Ki. The amounts of these K vitamins required to block development of the above syndrome differed with the various hydroxy-naphthoquinone derivatives. In each instance, however, vitamin Ki proved more effective than 2-methyl-1,4-naphthoquinone.

Observations made in this report confirm our earlier suggestion that the hemorrhagic syndrome, which results from administration of 2mdash;substituted — 3-hydroxy-1,4-naphtho-quinones, is due to competition between these substances and the K vitamins in processes involved in prothrombin formation.