Abstract
Summary
Fifty-four urine samples for 24-hour periods have been assayed microbiologically for free pteroylglutamic acid. For normal subjects the average 24-hour excretion was 2.3γ. Following an oral dose of pteroylglutamic acid the mean percentage recovery was 28.5%. Although the hospitalized patients studied had a similar excretion level (average 2.3 γ for 24hours) prior to dosage with pteroylglutamic acid, the percentage returns from single oral doses were much lower than in the normal subjects, a finding which is possibly indicative of a low degree of saturation.
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