Abstract
Summary
(1). An extensive list of pharmacolopical agents is presented. whose protective effects against the Salmonella endotoxin is reported as negative. The endotoxin of S.typhimurium was chosen for such tests because it is considered to be typical of the endotoxins generally found in Gram-negative bacteria. (2) Thiouracil and p-aminobenzoic acid have a limited protective effect against the lethal actionof the endotoxin. Thiouracil protects against endotoxin-induced tumor hemorrhage. It is concluded that these effects, as well as the similar effects of the sulfonarnides, is via a common mechanism, aiz., interference with thyroid activity.(3) Thiouracil has some protective effect against 1.2-dichloroethane, but is ineffective against colchicine. p-L4minobenzoic acid is likewise ineffective against colchicine. (4) Mice maintained at high environmental temperatures are more vulnerable to the endotoxin than those kept at lower temperatures. (5) The application of Selye's concept of “the general adaptation syndrome“ to the action of certainpoisons is briefly discussed.
Get full access to this article
View all access options for this article.