Abstract
Summary
The results indicate, therefore, that the oral administration of sodium benzoate in tablets in dose of 10 to 20 grains (0.65 to 1.3 g) every 4 hours for 6 doses totalling 60 to 120 grains (3.9 to 7.8 g) along with single intramuscular injections of 0.25 and 0.5 g (250,000 and 500,000 units) of streptomycin does not appear to reduce materially the urinary excretion of streptomycin, and does not enhance or prolong the maintenance of the serum levels of the compound. It is to be emphasized, however, that these preliminary results are inconclusive and, in view of the clinical importance of the subject in relation to the administration of streptomycin, additional investigations are being conducted.
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