Abstract
Summary
In this series of experiments it has been suggested that the mouse is highly resistant to histamine shock although regularly susceptible to anaphylaxis; that histamine administered either immediately before or after the antigen failed to potentiate the reaction; and that mouse serum in vitro failed to detoxify histamine for the guinea pig while guinea pig serum in vitro failed to make histamine toxic for the mouse. Further studies of the pathogenesis of anaphylactic shock in the mouse are in progress.
It is therefore concluded that there is no evidence at the present time that histamine plays a direct or significant role in anaphylactic shock in the mouse.
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