Mutual Depression of Reabsorption and Excretory Maxima in Renal Tubules

Abstract

Conclusions

In the dog, the maximum renal tubular reabsorption of glucose (Tm_G) and the maximum tubular excretion of p-aminohippuric acid (Tm_PAH) are mutually depressed when determined simultaneously. The percentile depression of PAH by glucose is twice as great as the depression of glucose by PAH. This depression is attributed to competition for available energy rather than to competition for a common cellular constituent (B substance) involved in tubular reabsorption and excretion.