Abstract
Summary
From 11.5 to 41 ± 5% of the total bone marrow was extirpated in 30 rabbits and the bone cavities were filled with inert material. The animals were allowed to survive for periods of 10 days to 14 months. Tissue changes were correlated with the quantity of marrow removed and the duration of survival of the animal. In some of the organs there appeared a cell infiltration of mature and immature granulocytes similar to that seen in human aleukemic leukemia. The marrow of the radius and ulna, normally aplastic for an adult rabbit, and the rib marrow showed marked cellularity in most animals. There was a considerable number of immature granulocytes in the marrow of some rabbits. The adrenal glands were increased in weight due to hyperplasia of the zona fasciculata.
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