Abstract
Summary
A series of derivatives of diphenyl sulfone, sulfoxide and sulfide were tested for in vitro tuberculostatic activity and for antituberculous therapeutic activity in guinea pigs. The following compounds, in addition to the reference materials 4, 4′-diaminodiphenylsulfone and its derivative diasone, showed high in vivo activity: 4-benzylideneamino, 4-aminodiphenylsulfone; 4-nitro, 4-acetylaminodiphenylsuLfone; 4, 4-di-aminodiphenylsulfoxide (hypo); 4, 4-diacetyl-aminodiphenylsulfoxide (oral). 4-Chloro, 4-aminodiphenylsulfide and the corresponding iodo derivative were highly tuberculostatic in vitro but were devoid of in vivo activity.
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