Creatine Concentration and Weight Loss in Denervated Skeletal Muscle

Abstract

Conclusions

Average dry weight ratios of denervated and intact muscles are not significantly different from average wet weight ratios on the 14th day after denervation. Creatine concentration parallels weight loss following denervation during the experimental period used. Although one determination appears to be as valid as the other in estimating the extent of atrophy it is evident that there is a greater net loss of creatine than can be explained simply on the basis of weight loss. Both weight loss and creatine loss are progressive with time up to 14 days after denervation.